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In our investigation we utilized %FEV1, the widely accepted criterion standard of acute asthma severity, in addition to secondary severity measures.
We used %FEV1 as the criterion standard to assess the diagnostic accuracy of PEP and used airway resistance and accessory muscle use as secondary severity measures.
Although these secondary severity analyses would be of lower statistical power and require replication, we propose that any positive results would reveal those pathophysiological pathways that warrant further investigation to see whether they can be exploited as potential therapeutic targets and prognostic and/or predictive biomarkers that may ultimately guide therapeutic decisions.
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Thus, hydrogels that reduce extracellular Ca2+ concentration may reduce secondary injury severity.
Subgroup analyses of algorithm accuracy were performed according to the diagnosis field in which the code for AH was recorded (primary vs. secondary) and AH severity (mild vs. severe), with a severe presentation defined by a Maddrey DF of ≥32 and/or the presence of hepatic encephalopathy.
Secondary outcomes, including severity of symptoms (categorised as either intermittent, mild, moderate or severe as per the US National Asthma Education and Prevention Program), were also stratified by gender and analysed with a 95% CI. 14 To determine if there was an association between exposure to environmental irritants and the presence/exacerbation of asthmatic symptoms, the OR was calculated.
Primary outcome measures were the reduction in migraine frequency and severity; secondary outcome measures included number of analgesics taken and the functional disability.
Secondary outcomes include severity of depressive symptoms, quality of life, anxiety and physical outcomes.
The secondary outcomes were severity of illness, length of ICU stay, and hypoglycemia.
Secondary outcomes were severity and etiology of re-injury and medical care.
Secondary outcomes were severity of subsequent self harm, mood disorder, suicidal ideation, and global functioning.
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