Exact(1)
The secondary, repeated measures analysis in the ITT population showed the mean weight gain across the 52 week time period (to weeks 3, 6, 12, 20, 28, 36, 44 and 52) was consistently numerically lower in the postmeal than in the premeal arm, although these differences were not significant at any time point [week 52: postmeal premeal = −1.1 kg with 95% CI (−2.28 to 0.13)].
Similar(59)
We conducted a secondary repeated-measures analysis excluding from the model data at 17 years of age to investigate associations before the onset of puberty.
Repeat A is present in the first unknown gene, repeat B in the pentatricopeptide repeat (PPR -like 1 gene and both of the secondary rePPR -likees, A' and B' are contained within the PPR-like 2 gene.
Sideroblastic cardiomyopathy secondary to repeated blood transfusions is a feared complication in thalassaemia.
However, these biotherapies present several drawbacks, including primary and secondary resistances, repeated injections, side effects, and prohibitive costs.
However the methods used (reusable sample chambers) was suboptimal: a significant cell loss can be attributed to the roughness of sample chamber walls secondary to repeated cleaning [ 13].
Following exogenous administration of large amounts of iron secondary to repeated transfusion, serum transferrin is highly saturated and there is an excess of non-transferrin-bound serum iron.
For the analysis of secondary outcomes, repeated measures analysis in line with that used for the primary outcome will be used for the monthly POEM measure up to 1 year.
Amlodipine for Myocardial Iron in Thalassemia (AMIT) is the second randomised control trial to date aimed at assessing the role of amlodipine in reducing moderate-to-severe myocardial iron load secondary to repeated blood transfusions.
According to the original glucocorticoid cascade hypothesis [ 11], chronic exposure to glucocorticoids throughout life, secondary to repeated or traumatic stress, downregulates the central glucocorticoid receptors, especially at the hippocampal level.
Liver injury secondary to repeated dosing of paracetamol should be considered when a child has received more than 75 mg/kg/day for at least 2 days or if risk factors for paracetamol toxicity exist [ 6].
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