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The Federal Deposit Insurance Corporation, a secondary regulator, was pushing to impose tighter regulation, but the primary regulator, the Office of Thrift Supervision, was successfully resisting allowing the F.D.I.C. to even look at the bank's loan files.
As if to give further evidence of its capture, OTS even went so far as to thwart an investigation into WaMu by the Federal Deposit Insurance Corporation, a secondary regulator, that could have put a stop to some of WaMu's unsustainable business practices before they did so much damage.
Thus miR-34a expression is dependent upon a secondary regulator.
The incretins are important secondary regulator hormones and exert modest effects compared with, for example, insulin itself.
The repressor is the primary regulator necessary to reduce expression from the promoter; the activator in this case is the secondary regulator that "antagonizes" the activity of the repressor to bring about activation of an otherwise repressed promoter.
The activator is the primary regulator necessary to increase expression from the promoter; the repressor in this case is the secondary regulator that "antagonizes" the activity of the activator to bring about repression of an otherwise activated promoter.
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There is also the possibility several indirectly regulated proteins may be regulated at a tertiary level involving secondary regulators that control expression of additional tertiary transcription factors that subsequently affect cyst development (Fig. 4).
Elaborate central control systems were devised, with a main regulator, branch mains, secondary regulators, and valves.
Throughout differentiation, secondary regulators such as ligand-activated vitamin D receptor (VDR) are recruited to the same genomic enhancers as RUNX2 to modulate the actions of RUNX2 for lineage-specific gene expression.
When using tissue explants, however, it is inherently difficult to distinguish between primary mitogens and secondary regulators of mammary gland function/development.
Moreover, as additional TCST systems with secondary regulators are disclosed by bacterial genome sequencing and functional studies, knowledge regarding the function and structure relationships of the LevQRST complex should prove valuable for expanding our understanding of the interactions between core TCST components and accessory regulators.
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