With time and repeated relapses, recovery is less complete and a gradual clinical progression known as "secondary progressive MS" occurs.
*, Secondary Progressive (n = 22) and Primary Progressive (n = 2); **, P < 0.05 for comparisons between Relapsing Remitting and Progressive persons.
It's possible it's gone into what's known as secondary progressive, which means drugs will be of less help.
About 65% of people with RRMS may develop secondary progressive MS, involving fewer or no relapses but increased disability.
Secondary progressive MS — which Ms Van Den Borne has — is when symptoms gradually worsen over time.
Most people with relapsing-remitting disease eventually develop secondary progressive MS, in which symptoms worsen as the brain atrophies.
After about 10 years, however, half of these patients go on to develop "secondary progressive" multiple sclerosis, in which patients gradually worsen between flare-ups.
The Food and Drug Administration approved mitoxantrone, which will be sold under the name Novantrone, for patients with the secondary progressive form of the disease.
These clinical and radiographic effects suggest that S1P receptor modulation might be effective in secondary progressive MS (SPMS).
Primary and secondary progressive multiple sclerosis (MS), collectively called progressive multiple sclerosis (PMS), is characterized by gradual progression of disability.
Eriksson, M., Andersen, O. & Runmarker, B. Long-term follow up of patients with clinically isolated syndromes, relapsing-remitting and secondary progressive multiple sclerosis.
