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Any increase in virulence or host adaptation would require a reassessment of the risk analyses relating to the possibility of a significant secondary outbreak of vCJD.
If leuko-depletion is ineffective in preventing transmissions via red cell transfusions we would expect the secondary outbreak to be up to twice as large, whereas a less effective donor ban had very little effect on the outbreak size.
If the test sensitivity of the prevalence test is lower, the true population prevalence is higher than measured in the appendix study, leading to more secondary transmission and therefore potential for a larger secondary outbreak.
However, there has been little systematic quantification or characterisation of secondary outbreak cases worldwide.
One other secondary outbreak linked to the cruise ship has been reported (2 ).
While some countries do report population based figures for secondary spread[ 6, 24], there has been little systematic quantification of secondary outbreak cases, particularly at an international level.
Similar(41)
Some patients who had been at Tan Tock Seng in March contracted the disease and later went to other hospitals when they developed coughs -- setting off secondary outbreaks.
Thus, it is possible that secondary outbreaks may occur through iatrogenic transmission via organ transplantation, contaminated surgical instruments, and human-derived therapeutic products; indeed, four cases of blood-borne transmission of the vCJD prion agent have already been documented in the UK.
Further research is necessary to determine if secondary outbreaks in sows could be prevented via vaccination and or boosters.
Once the unpredictable primary outbreak occurs, this large population of adult A. planci that reproduces enormous amounts of eggs can lead to secondary outbreaks.
We explain throughout the article that this work concerns primary transmission events and not secondary outbreaks, and therefore experimental drugs and containment efforts are not immediately relevant.
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