Bile duct epithelial dysplasia and fibrosis are secondary occurrences in patients with pancreatic cancer.
Thus, a next important step would be to conduct a comparative study in a larger cohort of patients to define and assess those thresholds in predicting mortality and/or secondary infection occurrence and to evaluate how they interface with usual values from HLA-DR as ABC obtained with standard protocol.
Of noninvasive diagnostic methods FDG-PET scans are among the few options capable of identifying early recurrences or secondary tumor occurrence [ 11].
Current studies have linked secondary leukemia occurrence to older age [ 8- 10], chemotherapeutic agents and dosage (epirubicin, doxorubicin and cyclophosphamide) [ 11, 12], radiation treatment [ 13] and supportive treatment with granulocyte stimulating growth factor (GCSF) [ 14- 16].
The length of time required for secondary CNV occurrence might derive from the time to and long duration of AAV-mediated gene expression in the mouse eye which has previously been demonstrated (Schlichtenbrede et al., 2003; Kjellstrom et al., 2007; Shao et al., 2012).
However, these observations and their possible cause-effect relationships require further confirmation in a larger longitudinal study with more detailed epidemiological data collection to enable the development of quantitative rules to exclude random effects and to differentiate primary clusters from secondary re-occurrences in low-endemicity settings.
Clinical data were collected prospectively, especially severity scores [PIM2, PELOD2 and Cumulative Vasopressor Index (CVI ], and secondary nosocomial infection occurrence.
Subsequent objectives were to assess the associations between inflammatory response, potential immunosuppression and secondary acquired infection occurrence.
We note that a secondary peak of occurrence rate, which should appear over the Pacific Ocean (e.g. Stolle et al., 2006, figure 5), is missing.
Owing to the sample size, no multivariate regression could be performed to test independence between mHLA-DR and cytokines for the prediction of risk of secondary acquired infection occurrence.
