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Outcome measures: primary, achievement of target peak/trough levels of aFXa; secondary, monitoring the effect of concomitant administration of noradrenalin on aFXa levels.
Secondary monitoring means that patients were presenting after primary UC diagnosis and treatment In Datasets 1 3 and 5, cytology and NMP22 were measured using the methods described by O'Sullivan et al. [ 18] and Cxbladder Detect was measured using a method based on O'Sullivan et al. [ 18].
However, in the this study the contributing datasets were different in terms of patient origin (Australasia and USA), primary detection or secondary monitoring of UC and the degree of imputation of the various tests – FISH was most imputed and affected, and in contrast, Cxbladder Detect and cytology were least imputed and least affected by imputation.
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