During metastatic disease, cancer cells leave the primary site (reduced adhesion) and go to the secondary environment (migratory activity).
Whether cell death is triggered directly by the failure of cell migration or is a secondary consequence of migratory failure for example, as a result of incorrect routing of axons produced by neurons within the clusters it represents an impressive demonstration of the rapidity and efficiency with which the developing nervous system recognizes and eliminates errors.
The striking deficit in inhibitory synaptic function observed in Lhx6 null mutants could be secondary to the migratory defect associated with deletion of Lhx6, as failure of interneuron precursors to reach their final destination on time could prevent them from establishing functional connections with their post-synaptic targets.
The failure of preplate neurons to polarize in the absence of RELN or SFK signaling could be a consequence of the defects in radial glial morphology previously described in reeler or a secondary consequence of the migratory defects observed in neurons of the reeler ectopic cortical plate.
Surveys of bird communities found greater species diversity in managed cacao (144) than in forests (130) or than in abandoned cacao fields (131), likely due to the propensity of most migratory birds to utilize secondary habitats during the non-breeding period (Reitsma, 2001).
An important decline in turtle diversity through the HCFm, previously attributed to climate, is shown to coincide instead with changes in soil drainage conditions, where aridity, landscape instability, and migratory barriers possibly acted as secondary limiting factors to faunal recovery.
This property is responsible for higher migratory aptitude of tertiary carbon atoms over secondary and primary.
Collectively, these data argue that PKD2 does not play an important role in mediating adhesion and migratory responses of lymphocytes into, and positioning within, secondary lymphoid tissues in vivo.
The virus' presence in wild birds leaves open the alternative possibility that migratory birds may have been the primary source, with secondary spread possibly caused by human-related activities.
Suppression of HAS2 in MDA-MB-231 breast cancer cell line displayed decreased cellular proliferation with a transient arrest in a cell cycle, ablation of migratory phenotype, alteration in hyaluronan catabolism, and inhibition of primary and secondary tumour formation [ 14].
