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For the second gene, the locus identifier becomes a secondary locus ID (associated with the first one), whereby the second gene's name and symbol will become synonyms of the first one.
In contrast, the Oxford-GlaxoSmithKline study reported a secondary locus distinct from rs6495308 (62).
Cutaneous infection can be a secondary locus in patients with disseminated infection from the respiratory tract.
To identify possible allelic variants of K-Channel genes in zebra finch, we BLAT-aligned each ortholog and analyzed any BLAT alignments at a secondary locus that had an identity score > 95% sequence identity.
Unfortunately, none of the published studies has used sufficient samples to compensate for these statistical penalties, and thus none is able to provide unequivocal evidence supporting any particular secondary locus.
Two groups have typed dense microsatellite maps of the region and both found evidence for a secondary locus maximal in a region close to HLA- A: one group identifying the marker D6S1683 just telomeric of HLA- A, 11 and the second group implicating a region including HLA -A extending from MOGCA to D6S265 marker.
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According to the model proposed by Grissa et al. [22], YPb and YPc would represent secondary loci produced from an initial locus (YPa) containing and providing all the necessary machinery.
Several authors have attempted to identify secondary loci using more powerful association-based methods.
No secondary loci were detected in any of the one-dimensional genome scans when controlling for the primary locus that was detected in each analysis.
INDEL markers for the gamma-TMT gene described by Hass et al. [ 14] were not polymorphic between nmsT2100 and IAST-1 or showed polymorphism in secondary loci.
Moreover, the investigation of secondary loci interacting with primary QTLs indicated that many QTLs that would be missed by single-locus tests would be detected through two-stage analyses and thus would allow the identification of more interactions [ 147].
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