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One must not confuse cases of Paget's disease with inflammatory carcinoma in which there is diffuse erythema involving the entire breast with secondary involvement of nipple and areola.
Lymphoma of the musculoskeletal system involving the bone, muscle or skin is commonly due to secondary involvement from disseminated disease but can occasionally present as primary extranodal disease.
Secondary involvement of the gastrointestinal tract is extremely common, usually from direct extension from involved mesenteric or retroperitoneal lymph nodes and consequently multiple sites of involvement do occur.
Secondary involvement of the thyroid gland by malignant metastases should be kept in mind when examining cytological and histological specimens.
The existence of such mixed mode coordination was confirmed by Extended X-ray Absorption Fine Structure (EXAFS) analysis, which was also consistent with adsorption to phosphate sites at low pH, with secondary involvement of carboxyl sites at high adsorption density (high pH).
Secondary involvement can occur via direct extension from the retroperitoneum.
Treatment is addressed to the primary disease in patients with secondary involvement of the HFP due to adjacent disorders [12].
Secondary involvement of the liver can occur in up to 50%% of patients with non-Hodgkin lymphoma and in around 20%% of patients with Hodgkin disease [1, 2].
The definitive histology diagnosed a large B cell lymphoma, present in 20 out of 24 removed lymph nodes, with an ovarian secondary involvement.
Enlarged lymph nodes also, both in the case of secondary involvement or primary lympho-proliferative disorders, may alter staging and/or treatment options in patients with cancer.
The pathophysiology of the two conditions is different since VKH is primarily a diffuse stromal choroiditis with secondary involvement of the choriocapillaris, whereas as CSC occurs a result of choroidal vascular hyperpermeability.
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