Sentence examples for secondary inhibitory effect from inspiring English sources

Since inhibition requires higher concentrations than activation (fig. 4A vs. fig. 8F) it is likely that these effects rely upon action at different interactions sites, as has been suggested for the secondary inhibitory effect of retigabine [18], [24], [31].

In addition bafilomycin may also have secondary inhibitory effects on autophagy vesicle processing [36], [40], [49], [50].

In the current study, we confirm that oxamate has anti-growth effects on breast cancer cells in vitro and in vivo but find that the cytostatic effects are secondary to inhibitory effects on mitochondrial metabolism rather than glycolysis.

The discovery of abyssomicin class of natural products has been the outcome of the search for secondary metabolites possessing inhibitory effect on p-aminobenzoic (pABA) acid biosynthesis, a biosynthetic pathway found in many microorganisms but not in humans.

It is unlikely that this effect is secondary to estradiol's inhibitory effect on caloric intake, since diestrous and estrous rats consumed similar volumes of more concentrated sucrose solutions and intake of all concentrations of non-caloric saccharin was suppressed during estrus.

In Stark and colleagues' study [ 10], this could reduce power to detect association by studying cases with secondary gout, since the inhibitory effect of diuretic medication on organic anion transporter 4-mediated renal urate excretion would predominate over the genetic effect on gout risk mediated by the SLC17A1 locus.

The attached prodomain typically undergoes a secondary cleavage event to relieve its inhibitory effect; however, the prodomain of secreted PCSK9 remains intact and tightly bound in the catalytic site, rendering the mature enzyme catalytically inert [ 14].

(K ) Quantification of the number of secondary branches per SGN ending showing the inhibitory effect of Sema3F-Fc.

This might reflect an increased degree of remodeling due to vitamin D deficiency and secondary hyperparathyroidism, or the absence of the inhibitory effect of a bisphosphonate.

In the secondary screening, compound 1 (Ginkgetin) exhibited the most potent inhibitory effect on Wnt signaling in a dose-dependent manner with a calculated IC50 of 5.92 ± 0.24 μΜ (Fig. 1b).

We first established that the inhibitory effect of glucose on glucagon secretion is secondary to glucose metabolism.