Photoreceptor cell death during primary RD is topologically independent and generally there is no evidence for inflammation, although an upregulation of innate immunity and secondary infiltration of microglial cells into the ONL has been reported.
We suggest that apoptosis of the hypertrophic chondrocytes induces secondary infiltration of osteoblastic cells through the expression of transcriptional factors such as Runx2, Osterix, Dlx5, and AP-1 [ 41- 43].
Multivariate analysis corroborated that the occurrence of precancerous lesions (HR, 3.773, p = 0.005), and more incisively the presence of SDC2 in the stromal compartment (HR, 7.652, p = 0.007), but not GPC6 expression or gender of the patient, were independent prognostic markers for post-surgery secondary infiltrations of lymphnodes (Table 4; Figure 5).
It leads to hemorrhage, edema and secondary inflammatory infiltration of the pulmonary interstitium and alveoli [16].
As to distant metastases, intestinal metastasis from GC is rare; however, the most common cause of secondary neoplastic infiltration of the colon is GC [19].
Retroperitoneal involvement is secondary to infiltration of the fat and surrounding structures by histiocytes and associated fibrosis.
Small volume mesenteric nodal involvement can also be seen secondary to infiltration by carcinoid tumour, malignant melanoma, breast, colon and lung cancers.
Multiple sclerosis (MS) is characterized by perivascular inflammatory infiltration, secondary demyelination, and axonal loss in the central nervous system.
In HES, the underlying cardiac pathological condition is thought to be a myocarditis secondary to eosinophilic infiltration of the myocardium (eosinophilic myocarditis, EM).
Additionally, inflammatory signaling and infiltration secondary to hypoxia is clear drivers of tumor progression [ 4].
Chronic inflammation of the liver secondary to triglyceride infiltration could increase the production of factors that cause systemic insulin resistance.
