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Migraine headache is probably caused by activation of nociceptors in the meninges and cerebral vessels and by secondary, increased pain sensitivity in the central nervous system [7].
Theoretically, when used for cardiac arrest, epinephrine increases systemic vascular resistance with secondary increased coronary blood flow, but there has long been concern that it also causes myocardial dysfunction when used in the arrest setting [ 4].
In KKAy mice with ectopic overexpression of agouti peptide, an endogenous melanocortin-4 receptor (MC4R) antagonist, social isolation promotes obesity due to the primary decreased energy expenditure and secondary increased food consumption [ 1].
Some theories suggest that NSCLBP is linked to a reflex response of the back extensor muscles, resulting in a loss of flexion relaxation of the back muscles and a reduction of spinal flexion with secondary increased tissue strain [ 39].
There was also a significantly higher prevalence of active syphilis in males as compared to females, which is consistent with recent reports in which the ratio of males to females with syphilis (primary and secondary) increased from 1.5 in 2000 to 8.2 in 2011 [ 19].
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In broad outline it appears that the local expression of decreased stress is an increase in bone resorption coupled variably with a smaller and secondary increase in bone formation, whereas increased stress appears to be accompanied by a decrease in bone resorption coupled also with a smaller and probably secondary increase in bone formation.
Also, there was a statistically significant secondary increase in EROD activity after 10 days of exposure.
First, there is an elevated activity of NADPH oxidase and NOS, with secondary increase production of ROS and reactive nitrogen species [69] (Fig. 1).
Secondary thermophilic microaerobic treatment (STMT) during anaerobic digestion helps in reset the digestion process by buffering the pH and increasing the microorganism activity, which provides a secondary increase in biomass degradation.
In 1% agarose gel, colony diameter displayed a significant increase after 12 hours, followed by a secondary increase after 72 hours for seeding densities: 1.9×108, 3.8×108 CFUs/mL.
We failed to observe in GRPC6A null mice evidence of secondary increase PTH or increased bone turnover that would be expected if GPRC6A ablation resulted in a renal calcium leak.
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