Of main interest with respect to a primary or secondary dysfunction of left OT regions is the activation pattern shown by the present dyslexic sample.
Let us first consider expectations from an only secondary dysfunction, that is, less engagement by lexical whole-word recognition and sublexical multi-letter recognition of otherwise fully functional left OT regions.
The hallmark is the absence of T cells, with a primary or secondary dysfunction of B cells, leading to hypogammaglobulinemia.
If only T cells are affected, with a secondary dysfunction of B cells, patients are characterized as T B+ SCID.
The inflammation leads to compression and secondary dysfunction of the structures within the cavernous sinus, including cranial nerves III, IV, and VI, as well as the ophthalmic and maxillary divisions of the trigeminal nerve resulting in clinical symptoms [ 1- 7].
With time these alterations cause secondary cellular dysfunctions and vascular damage including diabetic nephropathy, retinopathy, neuropathy, and macrovascular disease or vascular alterations.
Further objectives are to prevent the development respectively the progression of secondary organ dysfunctions or organ failure (like heart or renal failure or cerebral complications).
Alternatively, an increased risk of developing infections may be the result of immune dysfunction secondary to autonomic dysfunction that may accompany ICU-AW [ 28, 29].
Mitochondrial dysfunction can be of primary (inherent) or secondary (acquired dysfunction) origin [7], [32].
I forget whose idea it was, but it really got thrown by the wayside – the idea that primary organ dysfunction, for example pulmonary contusions or pneumonia, is different from a secondary pulmonary dysfunction in ARDS.
