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Importantly, wild type mice developed immunity through the priming dose that protected them against a higher secondary dose.
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Our screen led to the identification of at least six novel compounds that exhibited validated selectivity in a secondary dose-response assay [see Additional file 8, Figure S4].
This differential response to ponatinib as compared with dasatinib was confirmed in a secondary dose-response study, which showed comparable drug sensitive profile for samples of the patient obtained at diagnosis and at R1. Exon sequencing did not show any ABL1 mutation that could account for the differential response to the two drugs.
Figure 1 Flow chart of the secondary routine dose in measles vaccination.
Y-90 activities were determined from a stock solution measured under calibration conditions with a Fidelis secondary standard dose calibrator.
Data were pooled statistically using the event rates calculated for primary (the 1-year OS, ORR, partial response, complete response) and secondary endpoints (dose reduction or cessation because of crizotinib adverse effects, and mean duration of PFS and stable disease).
While this treatment is likely better than no boost at all, the importance of a high recurrence rate of the disease is secondary to dose limitations of normal pelvic tissue with conventional EBRT.
Furthermore increase in secondary pneumococcal dose after influenza virus infection did not change the expression of CD83, CD86 and MHC-II on MoDCs treated with both the two pathogen significantly (data not shown).
However, dosing was later discontinued in the 5 mg/kg IV weekly cohort per protocol rules secondary to dose-limiting toxicities of rash.
This work aims to evaluate secondary neutron doses at a CTI cyclotron center using a thermoluminescent dosimeter (TLD-600).
The lack of data for a possible secondary neutron doses has increased due to newly designed cyclotron rooms.
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