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The LARGE protein is involved in glycosylation pathways and, when altered, a reduction in the molecular weight of α-DG (van Reeuwikj et al., 2007) and a secondary decrease of the protein α-2-laminin are observed.
An indirect effect of 1,25(OH 2D3 on bone resorption mediated by reduction of inflammation resulting in a secondary decrease of bone resorption can be excluded as a cause for this observation, because 1,25(OhasD3 has clearly no suppressive effect on inflammation in our treatment protocol.
Knockout of Tfam results in a loss of mtDNA (29) and overexpression of TFAM leads to an increase of mtDNA copy number (36), whereas decrease of the mtDNA copy number by other means, e.g. due to pharmacological inhibition of mtDNA replication, leads to a secondary decrease of TFAM protein levels (37).
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As an alternative hypothesis it has been proposed that decreased HBV replication by limiting HSP60 release from infected hepatocytes, results in a secondary decrease in the frequency of CD4 T cells with regulatory/suppressor capacity (Tregs).
In T1D, the magnitude of BG elevation at dawn first reported was impressive and largely secondary to the decrease of plasma insulin concentration overnight (1), commonly observed with evening administration of NPH or lente insulins (8) (Fig. 1).
Cumulative data from multiple experiments with 0.1 and 1 μM Dex are in Fig. 2b: in both conditions, induction in the cytosol is concomitant with (or secondary to) a decrease of the cell surface pool and this is followed, temporally, by protein release in the medium.
The Zn dendrites became coherent at a much longer time period which corresponds to a decrease of secondary dendrite arm spacing (SDAS) by 8.3%.
The main objective was to assess the decrease of secondary illness in household contact in the mask group vs. the control group.
All alloys are multiphase structure; the type and amount of secondary phase decrease with content of Cr increases.
The analysis of other trials testing the efficacy of facemasks use in households did not show a significant decrease of the secondary illness rate in their primary intent-to-treat analyses [7].
O2 exposure leads to inappropriate oxidation of the metalloclusters, decrease of protein secondary structure and further degradation [ 6].
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