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The motor phenotypes of mutant mice appeared later might be caused by secondary changes of the brain.
Our findings highlight the importance of documenting secondary changes of gene repertoires and expression patterns in other gene families.
They may be due to dilated ISF spaces or secondary changes of amyloid deposition in the leptomeningeal arteries.
In particular, an importance of making a similar type of efforts for other gene families to document unidentified genes and secondary changes of their expression patterns is underlined.
Patients with acute traumatic cartilage injury will probably benefit the most from prompt and aggressive therapy that can minimize cartilage damage, initiate cartilage repair, and prevent secondary changes of the subchondral bone.
Since both subunits are internalized through CME, this would suggest that either OPHN1 controls the selective endocytosis of GLUR1 homomers or loss of OPHN1 function leads to secondary changes of the AMPAR subunit composition with a shift toward more GLUR2-lacking AMPARs.
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The positive correlation of Contrast in vermis with disease duration further suggested the possibility of secondary change of texture feature in genetically vulnerable vermis as a result of migraine chronification with medication overuse.
Is the hope of effecting secondary changes part of the motivation for war?
Distinguishing benign headache from ominous secondary changes is of great importance, and can be challenging especially in an emergency setting.
Secondary changes from redistribution of tissue stress include fibrocartilage production, with disorganization of the annular architecture and increases in type-II collagen.
Inappropriate weight distribution and secondary changes like rotation of the third phalanx and reduction in horn quality then facilitate the formation of lesions like (Rusterholz) sole ulcers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com