After reviewing the article, the curator chose the more specific GO term 'high affinity secondary active ammonium transmembrane transporter activity' (GO 0015398), a child term of GO 0008519.
These findings are interesting from the point of view that the ion transport by the secondary active transporter (KCC4) upregulates the primary active pump activity (H+,K+-ATPase).
Their activity creates a proton electromotive force allowing the secondary active transport of inorganic ions, sugars and organic acids.
The genes that are annotated to have a role in transporter activity are primarily involved with either ion transport or secondary active transmembrane transport (Additional file 3B).
Accardi, A. & Miller, C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl− channels.
While LacY has become the prototype system for studying secondary active transport, many questions remain unanswered.
Secondary active transporters couple the uphill translocation of substrates to electrochemical ion gradients.
Some CLC proteins are channels that conduct Cl− ions passively, whereas others are secondary active transporters that exchange two Cl− ions for one H+.
EmrE is a small multidrug resistance transporter that has been well studied as a model for secondary active transport.
Based on the studies on representative channels, uniporters, and secondary active transporters, I seek to unveil the governing principles of membrane transport.
Nevertheless, the ability of these species to grow anaerobically indicates that ATP generation by F1Fo-ATPase is not essential, suggesting that electron transport is required for other purposes, such as secondary active transport.
