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'One-carbon metabolism' was the second top pathway affected by Hcy-thiolactone (Fig. 3a).
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Fatty acid biosynthesis was the second top hit pathway.
Furthermore, ERK/MAPK (Ingenuity score=9.38E 03) was the second top signalling pathway, known to have a key role in the pathogenesis of cutaneous melanoma (Meier et al, 2005), thus confirming the reliability of our study design.
Neuregulin signaling was ranked the second top significant canonical pathway (p = 0.005) supporting the hypothesis that this gene set represented growth factor (GF) signaling (Additional file 3).
While alternate possibilities discussed above could potentially explain cooperative kinetics observed for non-native acyl-ACPs in reaction with BmaI1, our best evidence so far supports a model involving random addition of substrates with acyl-ACP binding first to the free enzyme (top pathway in Scheme 1) more kinetically preferred over SAM binding first to the enzyme (bottom pathway in Scheme 1).
We first tested all the pathways collected in BioCarta and the top pathway in the Pfizer sample set is the Gleevec pathway.
We first identified the top 100 genes up-regulated in the metastatic samples in order to identify the top pathway(s) associated with metastasis.
Second, Top 10 Tweets.
Plus 980 was a second top.
United go second top of table.
Top pathway analysis results for lightgreen module.
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