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The antigenic cross-reactivity of Flavivirus antibodies is well known, especially after a second or sequential Flavivirus infection in the same host (11 – 15 ).
Because of the close antigenic relationships among many viruses in this genus, Flavivirus infections are difficult to differentiate by most serologic techniques, especially in persons or animals having a second or sequential Flavivirus infection (12 – 12 ).
In the case of dengue, enhancement of virus replication by heterologous flavivirus antibodies and T-cell activation are thought to occur in some patients during a second or sequential dengue infection, resulting in hemorrhagic fever or shock (15, 16 ).
The EMA comments that "second (or sequential) agent that may address the same types of pathogens could also be considered for an initial approval based on limited data taking into account that having a choice of agents available has several obvious benefits".
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Samples (A), (B) and (C) were used and were obtained after third, fourth and fifth sequential re-crystallization respectively.
In the present prospective "Association des gastroentérologues oncologues" (AGEO) study, we report the efficacy and tolerability of second-line FOLFOX chemotherapy in patients included in the FIRGEM trial with PC that progressed after first-line gemcitabine or sequential treatment.
Absorption models with hypotheses of first-order, first-order with lag time, or sequential zero followed by first-order absorption processes were tested for their ability to describe the absorption profile following s.c. administration.
For the quantitative analysis, z-stacks of the interpapillary epithelium (up to the fifth layer of cells) or sequential z-stacks reproducing the whole thickness of the papillae (up to three layers) were acquired from samples stained for Ki67 or phospho-histone PH3.
Second, byte sequential ordering of packets is needed when a packet is retransmitted due to RTO timeout.
To examine changes in obstetric pathways two cohorts were compared: all women with a first-birth during either 1994 1997 (82 988 women) or 2001 2004 (85 859 women) and who had a second (sequential) birth within 5 years of their first-birth.
According to Barden, most telecom service categories saw year-over-year price declines ease in the first quarter of 2006 versus the fourth quarter of 2005, marking the second sequential quarter of moderation.
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