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For Michael Fury, 62, a husband may be the second most significant addition of the year.
Uncannily, at a time when Tony Blair was hardly known, the lads still managed to pick the political nickname of Britain's second most significant postwar prime minister.
Senator Rand Paul may have staged a Senate-shaking filibuster Wednesday, but his was actually only the second most significant Republican filibuster of the day.
The Giro d'Italia is the second most significant bike race in the world after the Tour de France – which starts in Yorkshire this year (in case you hadn't heard).
The second most significant source was the background activity.
Initial straw MC was the second most significant factor influencing strawboard quality.
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It may have been the second-most significant victory of Rubin's embryonic career after his victory over McEnroe, the seven-time Grand Slam tournament winner.
It was the third PGA Tour victory for Snedeker and the day's second-most significant golf result, after Robert Rock's two-stroke victory over Woods, whom he was tied with for the 54-hole lead at the Abu Dhabi Championship.
The captain and leading scorer for Liverpool of the English Premier League, he is arguably the second-most significant import in league history, behind David Beckham.
Indeed, these three metabolites are the second-most significant metabolites in the metabonomic analysis after taurine.
The second-most significant cluster contained genes involving the vacuolar membrane (ARL8A, ATP6V1G2, SBF2, and STX8).
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CEO of Professional Science Editing for Scientists @ prosciediting.com