Sentence examples for second generation inhibitor from inspiring English sources

The second generation inhibitor darunavir inhibited mutant forms MDR-HM and ANAM-11, but was ineffective against prDRV4.

This agent represents a "second generation" inhibitor with greatly improved binding affinity and bio-availability compared to its open-chain counterpart.

The most favourable substitution produced a second generation inhibitor with a binding affinity for KLK4 similar to that of SFTI-1 for trypsin while selectivity was markedly improved.

This produced a second generation inhibitor (SFTI-FCQR Asn14) which displayed both a 125-fold increased capacity to inhibit KLK4 (Ki = 0.0386±0.0060 nM) and enhanced selectivity over off-target serine proteases.

We employed a second generation inhibitor of mTORC1, everolimus, and found that both cardiac contractile abnormalities and skeletal muscle abnormalities were largely corrected.

PI103 is a second generation inhibitor of class I PI3K with anti-tumour activity in a variety of human cancers [ 14– 16].

Second generation inhibitors afatinib and ceritinib are approved for use in the FDA and have shown some promise in patients who were previously treated with first generation tyrosine kinase inhibitors for EGFR or ALK (respectively) [19, 34, 36].

Using rational drug design, several hypotheses were devised to overcome resistance issues leading to the development of second generation inhibitors, providing clinicians and patients with greater therapeutic choice.

Several second generation inhibitors with greater specificity than Sorafenib are in development and one of these, PLX4032, appears very promising.

Second and third generation inhibitors specifically modulate P-gp, with the second generation inhibitors lacking the pharmacological activity of its first generation counterparts and with a higher affinity for P-gp.

Second generation inhibitors that block the pathway at the lower micromolar range (1-5 μM) have now been described.