The duration of complete response was defined as the time between the first documentation of complete disease resolution and the first documented observation of PD.
PFS was defined as the time from randomisation to the first documentation of disease progression or death from any cause and was documented according to RECIST 1.0 and assessed via blinded, independent central review (Motzer et al, 2008).
The collection also includes some of the first documentation of the Pequots' and Northeast Indians' contacts with Europeans.
His 1822 book, Confessions of an English Opium-Eater, was the first documentation of an opium addict to be published.
The study, which follows two previous articles in the journal Nature, is the first documentation of humans' improving the economy of walking.
In 1609, Henry Hudson provided the first documentation of swimming in the Hudson River, noting in his log that Indians swam to his ship as he sailed up the waterway on his way, he hoped, not to Poughkeepsie, but to China.
This is the first documentation of diet transitions in a juvenile Neanderthal, the researchers said in interviews, suggesting that the barium technique may open the way to a more rigorous exploration of early-life dietary history of fossil hominins.
The first documentation of water level declines in the alluvial aquifer occurred in 1927 (Engler et al. 1945; Czarnecki 2010).
The well-known sequential breakage of undersea communication cables after the 1929 Grand Banks earthquake was the first documentation of landslide-triggered turbidity currents (Heezen et al. 1954).
To the best of our knowledge, this is the first documentation of tanycytic ependymoma undergoing malignant transformation, one driven by a highly anaplastic mesenchymal component, corresponding to "ependymosarcoma".
