First, discontinuation of AChE inhibitors is a frequent event and may be related to the acceleration of the functional decline.
Recall since birth provides a picture close to reality describing the first discontinuation of exclusive breastfeeding strictly after the WHO criteria.
The end date was date of either the first discontinuation or switch of mood stabilizing medication, death, or the last documented visit.
First, discontinuation rates would differ between osteoarthritis (OA), rheumatoid arthritis (RA) and other musculoskeletal conditions for lack of efficacy, but probably not because of adverse events.
While poor patient adherence is possible in our population, reinitiation in our population was common and on average occurred 4 months after the first discontinuation.
Treatment switches were captured from the index date up to 60 days after the first discontinuation of the index treatment, or up to the end of the study period, whichever occurred first.
TTF was defined as the time from the date of randomization to the date of each of the following, whichever occurred first: discontinuation of treatment, disease progression, or death from any cause.
Dietary recall since birth as it is used in our study strictly emphasizes the WHO feeding definitions, focusing on the first discontinuation of exclusive breastfeeding or predominant breastfeeding [ 16].
