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Second, consolidation in weaker member states needs to be balanced by higher consumption in stronger EU countries.
This second consolidation is a telling indicator of the next stage for the more mature members of its portfolio.
After a pre-treatment with the already positively tested modifications, the new modifications were applied to stone as a second consolidation measure.
This indicates that replacement of the second consolidation course by autologous stem cell transplantation has no major impact on long-term survival as observed in the randomized AML 8a study performed at the same time in a younger age cohort [ 22].
This is certainly the case as the second consolidation step leaves us with 4959 distinct motifs with lengths between 5 and 30 bases, many more than the proposed number of approximately 940 C. elegans TF genes (Reece-Hoyes et al. 2005).
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One patient developed hemiparesis on day 34 of the first consolidation chemotherapy treatment.
Our findings, that most patients complete their first consolidation treatment, but then the percentage completion rate rapidly declines, supports this.
Of the latter 112 episodes 32 (28,6%) were during the second cycle; 25 (22,3%), 27 (24,1%), 17 (15,2%) and 11 (9,8%) during the third, fourth, fifth and sixth consolidation cycle, respectively.
In an amended Italian ATRA and idarubicin (AIDA) protocol for elderly patients, the second and third consolidation cycle of the original protocol was omitted, and intermittent ATRA maintenance was given to all patients.
The mean duration of neutropenia was 14 (range 13 19) days for the induction phase (ICE), 7 (range 5 11) and 5 (range 4 7) days for the second and the third consolidation cycle, respectively.
Two discontinued treatment during the first consolidation chemotherapy cycle (abnormal liver function; anorexia), and a further two during the final cycle (allergic reaction; abnormal liver function, nausea, and vomiting).
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