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In the bacterial vaginosis study, intercourse between the second and third doses had a negative association with preterm birth.
Patients who were randomly selected to receive metronidazole were analyzed for bacterial vaginosis and T vaginalis at 24 to 29 weeks and for preterm birth of <37 weeks of gestation, according to intercourse between first and second doses and between the second and third doses.
In the T vaginalis trial, sexual intercourse between the first and second doses or between the second and third doses did not influence the incidence of preterm birth (13% vs 17%; relative risk, 0.8; 95% CI, 0.3-2.1; and 16% vs 17%; relative risk, 1.0; 95% CI, 0.6-1.6; respecompared compared with no intercourse.
In the bacterial vaginosis trial, although sexual intercourse between the first and second doses did not influence the incidence of preterm birth (11% vs 12%; relative risk, 0.9; 95% CI, 0.6-1.5), sexual intercourse between the second and third doses was associated with a reduction in the incidence of preterm birth (10% vs 16%; relative risk, 0.6; 95% CI, 0.4-0.9 0.4-0.9ed with no intercompared
Seroprotection rates as measured by SRH were 57 77% and 78 88% after the second and third doses, respectively.
Following the first dose, the second and third doses were given in 24-hour time intervals in both protocols.
Similar(9)
During sequential administration, increasing the lipid dose of Doxil in each dose by the addition of empty PEGylated liposomes strongly attenuated the magnitude of the ABC phenomenon during the effectuation phase of a second and third dose of Doxil.
The median age at vaccination was 1.8, 2.9 and 3.9 months for first, second and third dose, respectively.
No DLTs were observed in the second and third dose levels, initially.
The events were equally divided over the three doses, and they took place on day 8, 37 and 23 following the first, second and third dose, respectively.
In the event of there being insufficient cells for three doses then cells will be allocated preferentially to the first, then second and third dose.
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