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Final;score = in;silico consensus;rank + DB presence,+, 2XDB_{STOFFIDENT},+, 4XDB_{MS/MS} The rationale for these boosting factors is given as follows: (1) Using database boosting In silico fragmentation tools have never been published as a stand-alone tool without searching structure databases [21].
Search strategies were customised for each electronic database according to their individual subject headings, syntax and searching structure.
Specialist librarians together with the reviewers developed database-specific search strategies according to the particular subject headings and searching structure of the databases (See Additional file 1).
A search strategy was developed in Medline for the electronic databases according to their specific subject headings or searching structure to search for papers describing both primary studies and systematic reviews (see online supplementary data search strategy).
A WHO specialised librarian and the trial search coordinator of the Cochrane Collaboration Pregnancy and Childbirth Group developed the search strategy for each of the electronic databases according to their specific subject headings or searching structure in collaboration with the reviewers.
Under the searching structure, PSO enhances the global search capability and search efficiency.
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Concerning specificity, both assays are equivalent, since they depend on the antibody efficiency to recognize and discriminate the searched structure in the cell context.
In ParaPep, one can search structure of a peptide using SMILES search option.
However, most of methods based on structural alignment cannot be used to search structures against large database, since it has high computational complexity.
For structured profile search problem, we first search each simple motif by aligning its profile with the sequences, and then search structured motifs with positional joins.
We introduced SMOTIF, a fast and efficient algorithm to search structured pattern and profile motifs in biological sequences.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com