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We call the converging path from a starting motif candidate to the final consensus motif a motif searching pathway.
The route from original assumed reference motif to the final converged motif is called a motif searching pathway.
Gaps in the network were first addressed by searching pathway databases for the missing enzymes and corresponding genes in other organisms whose genome is sequenced (A. thaliana, E. coli, and S. cerevisiae).
Since resampling does not assume known distribution of the data, and biological data are usually complex, it has been widely used in the bioinformatics field, such as transcription factor binding site searching, pathway analysis and genome-wide association studies.
During the process of constructing a pathway, a user constructs a node of the desired type, and assigns a compound to a node by searching Pathway for the name of a compound or gene symbol, using a compound information dialog for the node type.
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In this report, we proposed motif searching pathways and motif searching graphs to inspect whether or not the algorithm of RNAMotifModeler indeed has a good convergence property.
INOH pathway data can be queried and represented graphically through the INOH Client tool, which is a pathway navigation/editor tool for editing and searching pathways in the INOH database and provides an automatic layout function of compound graph pathways.
The inferred ADR-pathways associations can be used to interpret an observed drug-ADR pair through searching pathways that were associated with the ADR among pathways affected by the drug.
Users can search pathway-related data using keywords, molecular weights, nucleotide sequences, and amino acid sequences, or as possible routes between compounds.
On the other hand, gene names can be used to search pathways database but gene search using pathway names as a query is not supported.
In addition to the searched pathways, users can adopt orthologous information from the KEGG and/or Ensembl databases.
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