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However, M-H is inefficient in searching complex likelihood functions, especially for the multimodal distribution functions, because of the sampling structure of M-H algorithm.
The multi-try differential evolution adaptive Metropolis (MT-DREAMzs) algorithm is effective and robust in searching complex probability space, and it is incorporated into NSE to improve the performance of marginal likelihood estimation in this study.
Summary: Cytoscape enhanced search plugin (ESP) enables searching complex biological networks on multiple attribute fields using logical operators and wildcards.
This hypothetical searching complex must (a) find the specific GA-sequence, GA-Sequ0 (see Def {7}), that belongs to the associated loop containing the gene of the target protein P0 (see Def {6}) and (b) interact with it in order to initiate transcription in the associated loop(s).
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This ability to search complex fitness landscapes in parallel makes GP an attractive tool for optimizing NN to solve genetic epidemiology problems.
While searching for complex relationships, it is possible to find too many relationships between entities.
As exemplified by the volume of literature we had to screen, searching is complex with methods reviews.
One structure shows AAG making only nonspecific contacts with DNA, depicting a "lower-affinity" or "searching" protein DNA complex.
To facilitate the search process, Argonaute (Ago) proteins come together with miRNA, forming a dynamic search complex.
We suggest that experimentally observed internal states of the Ago-miRNA search complex may have the explicit biological function of speeding up search while maintaining specificity.
Extension of these tools to protein library design could complement rational protein design cycles in an effort to more systematically search complex fitness landscapes.
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