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This review covers the computational aspects of identifying small molecules, from the identification of a compound searching a reference spectral library, to the structural elucidation of unknowns.
To solve the first problem on having transient noise component within a pitch search interval, we need to skip the transient noise region while searching a reference pitch.
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ChimeraChecker is an ITS-specific method using BLAST (Altschul et al., 1997) to search a reference database for taxonomic anomalies.
The query sequence is divided into four non-overlapping segments (chunks), each of which is used to search a reference database, which is assumed to be chimera free.
Each pyrosequencing read is BLAST [24] searched against a reference database comprising >90,000 near full-length 16S rRNA gene sequences from the Ribosomal Database Project (RDP) [25].
This week, Facebook unveiled its search tool, which it calls graph search, a reference to the network of friends its users have created.
A Finnish study described the correlation between searches in a reference database by medical doctors and laboratory reports sent to the National Infectious Disease Register in Finland [15].
A more direct approach for taxonomic profiling is to classify metagenomic reads through homology search against a reference genes database.
For example, Megan [ 11] assigns taxonomic groups to query sequences based on BLAST search against a reference database, usually the NCBI NR.
Three more articles were found by searching reference sections, for a total of 57 relevant articles.
Then, a keyword search turned up a reference to MicroPatent, a patent and trademark research company.
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