This is sub-optimum and one may improve the performance by exhaustively searching v l and w l which optimises the performance while fulfilling the general rule for multicasting strategy as described in Section II-A3.
We describe in detail an algorithm for repeated grid-search V-fold cross-validation for parameter tuning in classification and regression, and we define a repeated nested cross-validation algorithm for model assessment.
The confirmation of protein identities will be carried out based on a library obtained from Proteome database search (v 1.4, Thermo Scientific, San José, CA) and prior data dependent analysis (DDA) of pooled plasma samples from COPD patients and healthy participants.
The database is integrated with analysis tools that include: (i) keyword search, (ii) BLAST, (iii) position-specific iterative BLAST (PSI-BLAST), (iv) FAO/WHO criteria search, (v) graphical representation of allergen information network and (vi) online data submission.
Second, we note that the specific search led to less than half the number of initial hits compared with the generic search (3299 vs 8210, respectively), but both searches identified a similar number of studies included in the final review (17 vs 21 and three duplicates).
We don't think of it as 'this search' vs 'that search'.
HMM profiles were then used to carry out database search vs P. falciparum proteins.
All spectra were searched vs the full human SwissProt database (downloaded 21 March 2012) with reverse sequence database as implemented in Protein Prospector for decoy matches.
To determine whether any of the HGT candidates are mitochondrial genes that were incorrectly assembled into the nuclear genome sequence, or are mitochondrion to nuclear HGT events, we performed a BLASTP (v2.2.29+) search vs all mitochondrial proteins available in the RefSeq database [ 67].
The above properties of IΓ and vectors incomparable with IΓ allow us to limit the search space V to find Pareto solutions.
