All potentially relevant studies have been searched on electronic databases such as PUBMED, CENTRAL and EMBASE.
To include more articles, we searched on the Scopus database and found additional seven articles.
The sequence identity is relative to the CLAU C. autoethanogenum genome sequence when protein BLAST searched on the NCBI database.
Protein domains were searched on the PFAM database (Pfam-A.hmm available at http://pfam.xfam.org/) using HMMER v3.1b1.
The sequence identity is relative to our C. autoethanogenum genome sequence when protein BLAST searched on the NCBI database.
Each substance of abuse was searched on the PubMed database using the keywords "addiction" and "SNPs" in July 2014.
First, BLAST searches on EST databases allowed us to identify other species in which PAD proteins are likely present.
As for searches, these can either be free text searches on specific database fields, such as files.name=experiment_122, or structured searches.
All databases were searched on March 1 , 2013
All databases were searched on 21 July 2011.
