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On the basis of mechanistic studies, a QM model was established to search the potential reactive fragments for mechanism-based inhibitors.
Therefore, to search the potential role of ethanol in the UPS pathway, we first measured the levels of the 20S proteasome constitutive subunits.
Users can also search the potential open reading frame (ORF) of the query sequence in the GetORF page, and then search protein sequences against TE profile-HMM (profile hidden Morkov model) database collected from previous studies (24, 35).
One unique feature of BmTEdb is that it allows users to search the potential ORF of the nucleotide sequence, and then search protein sequences against a customized TE profile-HMM database.
By transforming the 3D structure segments into 1D structural alphabet sequences through in-house tool (called 3D-BLAST [ 13, 14]), we can rapidly search the potential target proteins with similar binding environment against Protein Data Bank (PDB) [ 15].
This study reconstructed and identified the gene networks of cancer hub genes to search the potential key regulators of endometrial tumorigenesis and to identify regulatory relationships among cancer hub genes.
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As a song, movie, novel or poem is searched, the potential connections it radiates seep into society in a much deeper way than the simple publication of a duplicated copy ever could.
The intelligence agents take the responsibility of searching the potential suppliers, negotiation with the short-listed suppliers and evaluating the performance of suppliers based on the selection criteria with mathematical model.
Secondly, the proposed method searches the potential saliency support regions to measure the saliency of multiple objects at different scales.
By searching the potential region for points that satisfy the conditions in Eq. (30), the workspace of the mechanism is numerically determined as in Figure 7(a).
Possible crystal structures are predicted by systematically searching the potential energy hypersurface to identify its local minima.
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