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In the first step, RepeatMasker [ 29] with the CrossMatch algorithm and default settings was used to search repeats without specifying a custom library.
Thus, we recommend that future studies on ISs and MITEs may combine de novo and library-based methods, ideally IRs search, Repeats search and profile HMM search.
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The CNDP work of [12] utilizes a solution to the maximum-independent set (MIS) problem as a starting point for a local search, repeating the process until a desired termination criteria is reached.
The substitution model parameters were re-estimated and the heuristic search repeated.
The first search was executed on December 6th 2012 by a Life Science librarian from a medical library and, as an update of the search, repeated with saved searches on February 25th 2014.
The following data sources were searched in May 2010, September 2011 and the search repeated in December 2012 for updates: PubMed/Medline from 2001 to 2012 and EMBASE from 2001 to 2012.
When long tracts of non-coding sequence were apparent and tRNA genes were not detected using default settings, the cove cutoff score was reduced and the search repeated.
It searches repeats in all microsatellite sequences present in the database and fetches information on species name, family, repeats, size, repeat region, NCBI references, and primers for SSRs.
We constructed three different work-flows: two de novo pipelines that search for repeats sequences (called "Repeats search") and for Inverted Repeats (called "IRs search") and a library-based pipeline using HMM alignment profile searches.
Initial searches were carried out in November 2007, with electronic database searches repeated in March 2010.
Typically, people search for repeats in bacterial chromosome(s), but some repeat copies can also be located in plasmids.
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