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A 100-member combinatorial library of α-ketoamides, which was designed to search potent cysteine protease inhibitors, was generated by a parallel solution-phase synthesis.
The total numbers of TCM compounds from TCM Database@Taiwan were 61,000, and we employed the TCM compounds to search potent ligand as BACE1 inhibitor by docking study.
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Interest in agar or agarose-based pharmaceutical products has driven the search for potent agarolytic enzymes.
Therefore, it is necessary to search for potent alternatives against the drug resistance.
In the search for potent water-soluble 3-arylisoquinolines, several 3-arylisoquinolinamines were designed and synthesized.
Structure-guided design was employed in a search for potent and selective inhibitors of mammalian secreted phospholipases A2 (sPLA2s).
In search to potent natural antioxidant from plant-based metabolites, a comparative study was designed in present investigation.
Hence, the search for potent and selective DNA-PK inhibitors has particularly considered state-of-the art and several series of inhibitors have been designed.
In the search for potent dual norepinephrine and dopamine reuptake inhibitors, several substituted arylpiperazine tetrazoles were designed, synthesized and evaluated for their neurotransmitter reuptake inhibitory activities.
The search for potent and efficacious inhibitors of the enzyme HMG-CoA reductase (HMGRI) was the focus of considerable research in the 1980s.
The synthesized heterocyclic analogues of this molecule were evaluated in vitro for their AChE and BChE inhibitory activities in search for potent cholinesterase enzyme inhibitors.
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