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We also carried out a forward citation and bibliographic search of identified studies.
A full table of the Swiss Prot search of identified proteins can be obtained as an additional supplemental, Additional file 1: Table S1.
Blast-p search of identified protein sequences was performed against the NCBI non-redundant database with a minimum expectation value of 1×10−3.
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Bibliographic searches of identified articles were conducted to identify other relevant studies.
A systematic literature review was conducted of several databases, supplemented with web searching, hand searching of journals, and bibliographic searching of identified articles.
In addition to database searches, bibliographies of identified systematic reviews were hand-searched to retrieve studies not captured by the initial database search.
Using the search strategy described above, the search of Medline identified 1451 articles, CINAHL identified 317 articles and EMBASE identified 42 articles not identified in the MEDLINE searches.
Finally, we searched bibliographies of identified articles and working papers.
Studies were located through computerised databases and hand searching references of identified articles and reviews.
We also searched bibliographies of identified articles and reviews for additional references.
We will also search reference lists of identified articles and hand search key journals (eg, Academic Medicine, Journal of Physical Therapy Education).
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