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This realisation has engendered an intense search for efficacious chemopreventive intervention strategies using animal models of premalignant and malignant colorectal cancer.
This may in part reflect the abnormal tumour microenvironment, which acts to support the persistence and growth of cancer cells, and has resulted in the peri-tumoural stroma and its cellular inhabitants becoming an intense area of study in the search for efficacious therapies for HCC.
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While the search for an efficacious HIV-1 vaccine remains elusive, emergence of a new generation of virus-neutralizing monoclonal antibodies (mAbs) has re-ignited the field of passive immunization for HIV-1 prevention.
The goal for the next decade will be to use the current agents more intelligently, to match patients to drugs individually, and to continue the search for more efficacious antipsychotics and new add-on drugs for cognitive and negative symptoms.
The search for new efficacious treatment strategies is therefore warranted.
In our continued search for more efficacious and safer drug combinations for hematologic malignancies, we recently reported the synergistic cytotoxicity of gemcitabine (Gem) and clofarabine (Clo) in multiple myeloma cell lines and primary cells derived from patients with multiple myeloma.
This is a clinical important and meaningful question, as knowledge about factors influencing variance in pain is essential in the search for more efficacious pain treatment for fibromyalgia patients.
This variation becomes a hurdle in searching for effective and efficacious therapies and cancer management strategies.
The search for safe and efficacious agents for use in inflammatory conditions is ongoing with the objective to find new drugs which are efficacious but with few side effects.
The search for potent and efficacious inhibitors of the enzyme HMG-CoA reductase (HMGRI) was the focus of considerable research in the 1980s.
In our continuing search for safe and efficacious antifilarials, a series of novel chalcone-benzothiazole hybrids have been synthesized and evaluated for their Brugia malayi thymidylate kinase (BmTMK) enzyme inhibition activity.
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CEO of Professional Science Editing for Scientists @ prosciediting.com