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This prediction is based on domain boundary detection, sequence homology search, fold recognition, homology modeling, de novo design, and model evaluation.
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One morning, I searched "fold a fitted sheet," which I did know how to do, more or less.
Even though experimental studies so far have only identified phosphothreonine lyases in prokaryotic organisms, based on bioinformatics studies using profile-based searching, fold prediction and genomic neighborhood analysis, we have recently predicted a phosphothreonine lyase function for BLES03 proteins in humans (30).
Here we report the structural and functional characterization of gene products encoded in the M. tuberculosis genome, with the help of sensitive profile-based remote homology search and fold recognition algorithms resulting in an enhanced annotation of the proteome where 95% of the M. tuberculosis proteins were identified wholly or partly with information on structure or function.
"Also, when they do a room search, they fold our blankets back up," Maria added.
HMMerThread combines relaxed conserved domain searches with fold recognition to eliminate false positive, sequence-based identifications.
The domain organisation of the STYKs has been analysed extensively by various profile-search and fold recognition methods described in a later section.
To perform grid search, 5-fold cross-validation was performed to select the best pair of the parameter values that minimizes an error function, which was subsequently used to train classifiers for validation of classification performance.
To reconcile these two fundamental requirements we propose a search-and-fold mechanism that involves the coupling of protein binding and partial protein folding.
On another occasion, he and his head mechanic, Robert Ferrand, devoted months searching for fold-down trunks for two 1934 Packards.
We describe in detail an algorithm for repeated grid-search V-fold cross-validation for parameter tuning in classification and regression, and we define a repeated nested cross-validation algorithm for model assessment.
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