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LD participated in the design of the protocol, background literature search, contributed to the development of the search strategy, reviewed articles for inclusion from Search 1 and 2 (as third independent reviewer) and contributed to the manuscript preparation.
Search 1 identified 26 matches and search 2 identified 46 matches.
The search strategy performed was the following: First Search: #1.
To avoid duplication of papers, Search 2 was restricted to papers not identified in Search 1. Abbreviations: CKD chronic kidney disease, GFR glomerular filtration rate, ESRD end-stage renal disease, GEE generalized estimating equations, GMM growth mixture model.
The query time series from January 2004 through February 2009 for France were downloaded from Google Insights for Search, 1 of the 2 websites with Google Trends that enables downloading search trends from the Google database (5 ).
Search #1 AND #2.
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Table 3 Sets of three molecules retrieved in each of four searches Search 1 Search 2 Search 3 Search 4 Search 5 {A, B, C} {B, C, D} {C, D, E} {F, G, H} ?
Currently, only few algorithms take advantage of a combined discrete and continuous space search [ 1, 7, 11].
The use of various terms for the same topic, sometimes even synonyms, contributes to the completeness of the search [1].
In cheminformatics applications, the most popular optimization strategies are grid search [1, 2] and heuristic choice [3, 4].
A large value of the inertia weight gives global search while a small value can provide local search [1].
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