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During screening/enrollment, the physician recorded the subject's characteristics and provided this information to the clinical research coordinator, who then allocated the subject an ID and study drug based on the sealed allocation tables prepared by the secretariat.
Computer-generated and sealed allocation sequence lists are prepared according to the stratification variables and the trial medication packages are distributed accordingly.
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The physical principles that affect fault sealing include principal stress sealing, lithological allocation sealing, shale smear sealing, time allocation sealing and occurrence allocation sealing (Liu 1998).
A research assistant not associated with the trial sealed study allocations in numbered opaque envelopes that were opened in sequence at the time each man was enrolled.
Appropriate allocation concealment methods were reported in most of the studies, including the use of sealed envelopes, central allocation, and/or the use of coded packaging/containers that were identical in appearance.
Non-research staff carried out the randomisation using sealed envelopes containing allocation cards assigned by random numbers.
The randomisation list will be used to prepare numbered opaque envelopes with the group allocation sealed inside by a person not involved in the study.
Randomisation envelopes were prepared by a third party using a random numbers table blocked in groups of four and sealed until treatment allocation.
The patients were randomly allocated to salpingectomy group or aspiration group (1: 1 ratio) using computer generated randomization list and sequentially numbered sealed envelopes containing allocation information written on a card.
One hundred and sixty patients with ultrasound visible hydrosalpinx were randomized into salpingectomy group and aspiration group using computer generated randomization list and sequentially numbered sealed envelopes containing allocation information written on a card.
Only 1% (10/1077) of RCTs reported reasonable allocation concealment, including central allocation and sealed opaque envelopes; 99% (1067/1077) of trials did not indicate the allocation concealment method.
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