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Chemokines and extracellular matrix proteins per se induce thymocyte migration, and recent data suggest a combinatorial role for these molecules in this event.
Taken together that quiescent PSCs seeded onto stiffer matrices were observed to lose lipid-storing capacity, express the canonical markers characteristic of PSC activation, and increase proliferation & ECM protein production, these observations indicate that substrate stiffness can, per se, induce phenotypic transition of PSCs to a matrix-secreting active state.
In conclusion, this study provides unexpected evidence that in adult hearts changes in biomechanical stress per se induce a specific miRNA remodeling pattern which, however, does not determine the direction of the growth response in postnatal cardiomyocytes and does not resemble the fetal miRNA program.
Anesthesia does not per se induce these changes in our pig model.
Therefore one might expect that the switch of the microglial cultures to a medium containing 50% of C6 cell incubation medium could per se induce morphological changes.
A more recent development is the finding that increased adiposity, altered adipokines and/or inflammatory mediators (but not body weight per se) induce microgliosis [ 98], cytokine secretion [ 99] and neuronal dysfunction and death in the hypothalamus [ 100].
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During the second microdialysis experiment, a group of animals was subjected to SE induced by pilocarpine administration (300 mg/kg, i.p.; SE group).
Many studies did not measure systemic physiology and thus could not detect if the set-up or protocol per se induces changes, which might have led to misinterpretations of the results.
This work was designed to study the influence of drugs during seizures and status epilepticus (SE) induced by pilocarpine and mortality in adult rats.
FCCP per se induced the greater release of l-[14C]glutamate in hypergravity as compared to control (4.8 ± 1.0% and 8.0 ± 1.0% of total label).
Status epilepticus (SE) induces a number of events leading to programmed cell death (PCD).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com