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Further, disease-associated genetic variation at SE sites could lead to disease by disrupting non-coding RNA and/or SE function.
The Systems Engineering (SE) function within Thales UK seeks to minimize the impact of, or eliminate problematic SE projects.
If these seRNAs contribute to SE function, they could represent an additional avenue for manipulating SE activity.
He pointed to the need for better biomarkers of Se function to address each of these questions.
Such a scenario would be an efficient solution to tune dynamic changes rapidly and precisely in lineage-specific gene expression, consistent with the rheostat model of SE function that was recently proposed [ 33].
Small molecule BET inhibitors effectively disable SEs in tumor cell lines and stop cell growth [ 3], and we show that chemical inhibitors that abrogate SE function also block expression of inflammatory genes, as well as affect cell fate decisions in macrophages and T helper cells.
Similar(54)
In this definition of cause, per se functions to rule out cases where x depends on y, but not insofar as y is described as y.
Thus, the cuticle per se functions as an external structural element that adds mechanical support for tissue integrity [39].
Se functions in the antioxidant system are an essential component of a family of GPx enzymes.
Among Se functions, its antioxidant role, played through selenoprotein P (SePP) and the enzymes glutathione peroxidase (GPx) and thioredoxin reductase, has been emphasized in previous studies.
For this reason, potential SE functions are often tacitly sought and assumed to exist by researchers when deciding which causal roles among the (possibly infinite) list of options are worthy of investigation.
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