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Microarray screens published in the biomedical literature were additionally included in the c2 gene set.
Two recent high throughput screens published in 2013 did however identify several hits that progressed to animal studies that are FDA approved drugs used for other indications.
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A detailed analysis of low-dose cancer screening, published in today's New England Journal of Medicine, showed that the cost of adding one good year to a person's life through CT screening is around $80,000.
Many experts agree with Newman, and two large studies of P.S.A. screening, published in The New England Journal of Medicine in 2009, came to the same conclusion: There was no difference between the screened and unscreened groups in overall deaths.
As it happens, a screening published in 2013 showed that amodiaquine has anti-Ebola activity in the test tube.
We compared the final search with an archive of all articles on breast cancer screening published in 2004, which we have used for another study, 8 and found that we had not missed any potentially relevant papers.
Based on a pilot screen published in Lorenzen et al. [ 11] we have performed the first high-efficiency, large-scale insertional mutagenesis screen in an insect species outside the genus Drosophila, and we have established a crossing scheme that circumvents the need for balancer chromosomes or embryo injections.
The IARC Handbook of Cancer Prevention on breast cancer screening, published in 2002, concluded that the marginal cost-effectiveness of expanding a programme to younger women (aged 40 49 years) greatly depends on its effect on reducing breast cancer mortality as estimated from randomised controlled trials, 'and that it is likely to be more cost-effective to make other changes'.
The initial I-ELCAP screening study published in 1999 screened at-risk persons aged 60 years or older (Henschke et al, 1999).
In March 2012, the results of two large-scale pharmacogenomic human cancer cell line screens were published in Nature [ 5, 6].
The World Health Organization (WHO) screening criteria published in 1968 highlighted major concerns with the occurrence of false-negative screening results; as people with undetected disease continue to be a source of infection [ 2].
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