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The predictions were based on a small number of properties that were either calculated based on the structure of the candidate drug (octanol:water partition coefficient, ionization constant(s)) or obtained from the typical high-throughput screens implemented in the early drug discovery phases (fraction unbound in plasma and hepatic intrinsic clearance).
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One of the unexpected outcomes of compulsory hERG screening implemented in USA and European Union resulted in large datasets of IC50 values for various molecules entering the market.
Systematic screening implemented in parallel with ongoing opportunistic screening was introduced in 2006 [ 8] but has achieved only limited coverage (24% of the target population, women aged 30 to 59 years in 2009).
However, the DoH (England) document [ 5] is less prescriptive and suggests that "trusts should consider how local risk assessment can be done and screening implemented for these patient groups".
The sample was drawn from three general practices in suburban London, and subject to eligibility criteria and disability screening implemented for recruitment into a trial of health promotion, which may limit the generalisability of the results.
Although fever screening with infrared temperature screening was implemented in an attempt to avoid SARS transmission, it proved to be effective in active surveillance of dengue.
The model compared six strategies for CRC screening currently implemented by population-based screening programmes, and recommended by international guidelines and previous studies.
The screening programme implemented in Geneva 10 years ago targets women aged 50 69 years, and screening for breast cancer in women <40 years is rare (Lutz et al, 2000).
The effect of border screening on the total delay D is quite modest, though sensitive to how screening is implemented.
Furthermore, metabolic evolution approach with buoyancy screening was implemented for selecting a high lipid producing yeast strain.
Organised breast cancer screening was implemented in Norway during 1995 2005.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com