Sentence examples for screens focused on from inspiring English sources
Other genome-wide screens focused on genomic changes in parasites resistant to common malaria drugs.
Historically, these screens focused on mutations present in clonal outgrowths as evidence of their role in malignancy; however, recent pyrosequencing of MuLV lymphomas has also shown selection taking place within subclonal populations of cells2.
In fact, in the past decade, forward genetics has uncovered mutations demonstrating that certain genes exist only in mammals, that specific mechanisms function only in mammals, and that particular biological processes may exist only in mammals; hence screens focused on these processes have identified unsuspected genes.
While early screens focused on drug sensitivities driven by single tumor-associated mutations, the latest efforts have highlighted growth sensitivities driven by multi-parametric biomarker signatures6 or differentiation-based vulnerabilities associated with lineage7, clearly illustrating the advantages of the continued expansion of screening formats and analytical capabilities.
Some of the door opening screens focused on the door handle.
Several screens focused on certain aspects of membrane and vesicle transport.
Data on mutations and mutated genes were retrieved from three databases, 17 whole-genome resequencing studies and resequencing screens focusing on gene subsets (Table 1).
We used RNAi data from seven different, published genome-wide RNAi screens focusing on the three viruses HIV [ 10, 12, 53], HCV [ 13, 18, 54] and WNV [ 11].
These may be refinements of phenotypic analyses preparatory to screening, or phenotypic screens based on observation of alterations in development, morphology, or physiology; 7) screens focusing on identifying novel developmental genes and pathways.
Here we describe our methodology of multi-step mAb screening focused on identifying mAbs exhibiting efficacy and specificity in labeling mammalian brain samples.
Structure-based virtual screening focused on potential allosteric surface cavities revealed these compounds [1].
