In this work, we describe a plugin for PyMOL which allows carrying out 2D or 3D ligand-based virtual screenings of large small-molecule databases with immediate subsequent visualization of predicted ligands.
Many promising lead compounds are being identified through screenings of large biological and synthetic peptide libraries [9], such as phage displayed random peptide libraries,[10], [11].
In celebration, the museum will offer "The Best of Imax," twice-daily screenings of three large-format films.
The era of genome-wide high throughput technologies has sparked the initiation of genotype screenings in large cohorts of diseased and control individuals, but had limited success in identification of disease causing genetic variants.
Missense mutations found as a result of large screenings of patients with LQTS or Sudden Infant Death Syndrome, and which lack sufficient data to support their pathogenicity, were categorized as "possible pathogenicity" (Jongbloed, et al., 2002; Kapplinger, et al., 2009; Napolitano, et al., 2005; Splawski, et al., 2000; Tester, et al., 2005).
Processing of large-scale screenings of culture plates was facilitated by creating red-shifted, false-color images from standard photographs of the plates; this conversion allows for an objective and rapid discrimination between wells containing living cells and wells containing dead cells.
We pioneered this concept of large mental health screenings with the idea that even if people are just taking this one day to do a 'check up from the neck up,' then it makes a difference". Each assessment is anonymous and can be done online or at a participating mental health center.
This sensitivity of the luminescence assays with low sporozoite numbers in combination with the early detection of luciferase expression offers unique possibilities for large scale screenings of inhibitors of parasite liver stage development, with the potential for automation, using microplate assays.
Recently, results of two large repurposing screenings of Food and Drug Administration (FDA -approved drugs have been reported.
Hence, high-throughput screenings of microRNA function usually employ large synthetic libraries that cover the entire miRNome available for a specific organism.
Ecotilling was originally developed as TILLING for large scale screenings of chemically induced mutations in plants [ 16], and later adopted for human samples [ 13].
