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The screening was driven by a script that runs the docking of several ligands on a cluster of CPUs in parallel, allowing the full screening to be completed in a couple of weeks.
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It is clearly recognized that Down syndrome prenatal screening is driven by several primary forces: (i) effort to reduce "the costs of life-long care" of people with Down syndrome through prenatal screening; (ii) clinical support for individual choices of mothers or couples; (iii) public health strategies designed to reduce birth defects and improving reproductive outcomes [ 14].
A 6-amidinotetrahydroquinoline screening hit was driven to a structurally novel, potent, and selective FVIIa inhibitor through a combination of library synthesis and rational design.
The decreased risk was driven by the lower incidence of screen-detected tumours among these men.
The extent and nature of the infrastructure required by each screening centre is driven by their area of specialism and the size of their screening collections.
It's worth remembering that the introduction of breast screening has been driven, at least in part, by political motives.
But critics say that the move toward screening is being driven by corporate marketing and a political response to public fear.
This paper highlights a broader issue that decisions about screening may be driven by the availability of diagnostic testing platforms rather than the evidence base.
The choice between symptom and CXR screening may be driven by the availability, cost and mobility of CXR equipment, but should be balanced against the overall resource requirements for an active screening initiative and the expected yield.
Some programs use a combination of SRM and profiling with either approach, the screening test is driven more by analytes than by the conditions with which they are associated.
The popularity of large colour screens has been driven by the growing adoption of data services such as web-browsing and downloading games and screen graphics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com