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Three cost effectiveness acceptability curves of CAD versus double reading - one for each screening volume - are shown in Figure 1.
The additional cost of purchasing and upgrading CAD equipment varied according to the screening volume of the unit.
Screening costs were robust to screening volume (<5% variation if 2,000 women screened annually), but costs of colposcopy/biopsy tripled at the lower volume.
Previous studies have shown that as the screening volume increased, the average cost borne by the health care provider to serve one subject decreased, thereby approximating an inverse relationship [ 29].
In addition, the number of CAD systems and workstations that screening centres would purchase is difficult to estimate since this is dependent on both screening volume and the number of readers.
By contrast, the aggregate costs of screening procedures were relatively robust to screening volume (<1% variation when assuming 6,000 screened women per annum, and <5% variation assuming 2,000 screened women per annum).
Similar(51)
Assuming high screening volumes, it was found that the cost-effectiveness of primary careHPV screening compares favourably to that for visual inspection screening methodologies [ 5].
Microbioreactors have reached kL a values of 460 h-1, and are offering instrumentation and some functionality comparable to production systems, but at high throughput screening volumes.
Our baseline estimate of aggregate test costs was based on high screening volumes, and in this situation we found that the total cost of colposcopy is lower than that of careHPV screening.
Thus, the observed nanotube frequency shift corresponds to an effective screened volume of ≈ 1.7 mm3.
Even if the Fe formed a single large particle, which gives rise to the greatest screened volume, the contribution to increase in resonant frequency will be only 0.6% of that observed for the whole CNT sample.
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