In lead discovery, advances in chemoinformatics have led to the design of compound libraries in silico that can be screened virtually.
This assay can be performed with small quantities of total cellular extracts as a source of enzyme and can be used to rapidly screen virtually any potential inhibitor.
Indeed the pharmacophore notion provides a powerful way to identify and compare structural features across a large set of molecules and the possibility to screen virtually millions of compounds.
Candidate solutions can be screened virtually by performing a quantitative structure-activity analysis at each step, i.e. providing a computer model that effects a mapping between known structures and their fitnesses, then assessing the quality of potential leads in silico.
Kick-Ass is a remarkable vision to find its way to the big screen virtually unadulterated.
Several stage plays have come to the screen virtually intact with disappointing results; the most recent example is "The Producers".
By contrast Mr. Baldwin, on screen virtually every minute, seems locked in a freeze-dried portrayal, his demeanor scarcely changing through Kane's various scrapes and discoveries.
