Sentence examples for screening the efficacy from inspiring English sources

Improved methodologies for modeling cardiac disease phenotypes and accurately screening the efficacy and toxicity of potential therapeutic compounds are actively being sought to advance drug development and improve disease modeling capabilities.

Inhibition of dural PPE was once a major platform used in screening the efficacy of drugs such as sumatriptan for the treatment of migraine [26, 27, 94].

Our results provide methodological perspectives for screening the efficacy of these strategies on motor function in AIA rats.

Careful intensive care support enabled survival for about 60 hr in an anhepatic porcine model and may thus be a valuable tool for screening the efficacy and safety of liver support technologies.

Here, we applied two behavioral tests, including the sucrose preference test and the force swimming test, which have been developed as straightforward tests for screening the efficacy of antidepressants, to investigate whether E2 induces antidepressant effect.

Few high-throughput methodologies exist that measure cell compliance, which can be used to understand the impact of genetic alterations or to screen the efficacy of chemotherapeutic agents.

The PKCS model is a novel tool to test the pathophysiology of fibrosis and to screen the efficacy of anti-fibrotic drugs ex vivo in a multicellular and pro-fibrotic milieu.

The TNFtg model gained much interest and is now used in many labs to identify downstream pathways of TNF-induced joint pathology and to screen the efficacy of various TNF-directed therapies.

As yet, it is unknown whether precision-cut kidney slices (PCKS) can be used to study the development of renal fibrosis and to screen the efficacy of anti-fibrotic compounds, e.g. IFNγ.

Behaviour of the experimental rats was assessed during the 5th week of life (prepuberty) using the elevated plus maze (EPM), a valid test for assessing levels of anxiety-like behaviour [ 48], and the forced-swim test (FST), a putative assessment of depressive-like behaviour [ 42], originally derived to screen the efficacy of antidepressant drugs [ 49, 50].

IFNγ and PPB-PEG-IFNγ significantly reduced TGFβ1-induced fibronectin and collagen I mRNA expression, which was confirmed by immunohistochemistry. Implications and future directions The PCKS model described here is a novel tool to test the pathophysiology of early onset fibrosis and to screen the efficacy of anti-fibrotic drugs ex vivo in a multicellular and pro-fibrotic milieu.